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, , Di Zheng, BM Corresponding Author: Dr Di Zheng, Department of Anesthesiology, Hangzhou Plastic Surgery Hospital, 168 Shangtang Road, Hangzhou 310014, China. E-mail: zhengdi1@163.com Search for other works by this author on: Oxford Academic Xiaoyun Lu, BM Search for other works by this author on: Oxford Academic
Aesthetic Surgery Journal, Volume 44, Issue 6, June 2024, Pages NP357–NP364, https://doi.org/10.1093/asj/sjae033
Published:
10 February 2024
Article history
Editorial decision:
05 February 2024
Published:
10 February 2024
Corrected and typeset:
13 March 2024
A correction has been published: Aesthetic Surgery Journal, Volume 44, Issue 6, June 2024, Page NP443, https://doi.org/10.1093/asj/sjae099
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Yunping Huang, Di Zheng, Kai Xu, Jun Li, Yimei Gu, Zhiwei Yin, Junli Pan, Jian Shen, Xiaoyun Lu, Feifei Zhong, Yanfen Qiu, Randomized, Single-Blind, Comparative Study of Remimazolam Besylate vs Propofol for Facial Plastic Surgery, Aesthetic Surgery Journal, Volume 44, Issue 6, June 2024, Pages NP357–NP364, https://doi.org/10.1093/asj/sjae033
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Abstract
Background
Use of local anesthesia and conscious sedation with a combination of a sedative and anesthetic drug during a surgical procedure is an approach designed to avoid intubation, which produces fewer adverse events compared to general anesthesia. In the present study, a comparison was made between the efficacy and safety of remimazolam besylate and propofol for facial plastic surgery.
Objectives
The objective was to evaluate the clinical efficacy, comfort, and incidence of adverse events of remimazolam compared with propofol combined with alfentanil in outpatient facial plastic surgery.
Methods
In this randomized, single-blind, single-center, comparative study, facial plastic surgery patients were randomly divided into remimazolam-alfentanil (n = 50) and propofol-alfentanil (n = 50) groups for sedation and analgesia. The primary endpoint was the incidence of hypoxemia, while secondary endpoints included efficacy and safety evaluations.
Results
There were no significant differences regarding the surgical procedure, sedation and induction times, pain and comfort scores, muscle strength recovery, heart rate, respiratory rate, and blood pressure, but the dosage of alfentanil administered to the remimazolam group (387.5 μg) was lower than that for the propofol group (600 μg). The incidence of hypoxemia (P = .046) and towing of the mandibular (P = .028), as well as wake-up (P = .027) and injection pain (P = .008), were significantly higher in the propofol group than the remimazolam group.
Conclusions
Remimazolam and propofol had similar efficacies for sedation and analgesia during facial plastic surgery, but especially the incidence of respiratory depression was significantly lower in patients given remimazolam.
Level of Evidence: 2
© The Author(s) 2024. Published by Oxford University Press on behalf of The Aesthetic Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)
Topic:
- hypoxemia
- heart rate
- alfentanil
- anesthesia, general
- anesthesia, local
- anesthetics
- outpatients
- pain
- propofol
- safety
- single-blind method
- surgical procedures, operative
- pain management
- analgesia (pain absence)
- mandible
- sedatives
- sedation procedure
- respiratory rate
- respiratory depression
- muscle strength
- remimazolam
- pain during injection
- adverse event
- facial plastic surgery
Issue Section:
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